Cooperative motors
نویسندگان
چکیده
منابع مشابه
Cooperative motors
L eukocytes are more likely to grab onto a vascular surface when under fl ow than in the absence of fl ow. This counterintuitive behavior relies on bonds between transmembrane selectins on the blood cell and their vascular ligands. These so-called " catch bonds " get stronger because fl ow fl ips open selectin into a binding-ready conformation, Lou et al. show on page 1107. The authors have sol...
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We use a two-state ratchet model to study the cooperative bidirectional motion of molecular motors on cytoskeletal tracks with randomly alternating polarities. Our model is based on a previously proposed model [Badoual, Proc. Natl. Acad. Sci. U.S.A. 99, 6696 (2002)] for collective motor dynamics and, in addition, takes into account the cooperativity effect arising from the elastic tension that ...
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The transport of cargo particles that are pulled by several molecular motors in a cooperative manner is studied theoretically in this article. The transport properties depend primarily on the maximal number N of motor molecules that may pull simultaneously on the cargo particle. Because each motor must unbind from the filament after a finite number of steps but can also rebind to it again, the ...
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Motor proteins are specialized molecules that convert chemical energy into useful mechanical work and govern many important biological processes. They bind to actin filaments and microtubules and use them as tracks, on which they propagate in order to transport different types of cargo across the cell. Among these molecules we find myosin II motors that interact with elastic actin filaments. My...
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Recently, in a beautiful set of experiments, it has been shown that a Ncd mutant, NK11, which lacks directionality in its individual motion, was able to exhibit a new kind of directed motion in motility assays (Endow, S. A. & Higuchi, H. (2000) Nature (London) 406, 913-916): the filaments keep a given velocity for a while and then suddenly move in the opposite direction with similar velocity. W...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1747iti5